Biocept Broadens Commercial Focus of its Target Selector Liquid Biopsy Platform to Include Urology Market Segment
"The new uro-oncology biomarkers included in
"We are excited to expand our commercial offering into the urology market segment with the new biomarkers incorporated into our EmpowerTC service," said
About Liquid Biopsy Biomarker Detection for Prostate Cancer
Prostate cancer is a leading cause of cancer death in the United States with 31,620 deaths and 174,650 new cases estimated for 2019.1 The disease is diagnosed from pathologic evaluation (Gleason score) of needle-based tissue biopsies, and biopsy tissue is used to determine prognosis and guide treatment. However, prostate cancer is a multifocal disease and a needle biopsy often misses a potentially relevant tumor; there can also be significant variation within pathologic evaluation of a specific tumor.2,3 Liquid-based biopsy biomarker detection may address tumor heterogeneity and enable more-informed prognosis.
Patients who present with advanced disease typically receive chemical castration with androgen deprivation therapy (ADT) or surgical castration as initial treatment to reduce androgen-driven tumor growth. However, most prostate cancer patients acquire resistance to the initial treatment, thus progressing to a castration-resistant disease state.4 Prognostic markers can help suggest the patient's overall outcome, such as the probability of biochemical recurrence or metastasis, and prognostic markers may be useful to guide patient management. Predictive markers aim to evaluate the likelihood of benefit from a specific clinical intervention. Liquid biopsy provides the ability to assess both prognostic and predictive biomarkers such as androgen receptor (AR) overexpression, circulating tumor cell (CTC) enumeration, the genomic biomarkers PTEN, MYC, C-met, EGFR amplification and AR splice variant-7 (AR-V7), which offer promise in meeting this important medical need.
About
About
Forward-Looking Statements Disclaimer Statement
This release contains forward-looking statements that are based upon current expectations or beliefs, as well as a number of assumptions about future events. Although we believe that the expectations reflected in the forward-looking statements and the assumptions upon which they are based are reasonable, we can give no assurance that such expectations and assumptions will prove to have been correct. Forward-looking statements are generally identifiable by the use of words like "may," "will," "should," "could," "expect," "anticipate," "estimate," "believe," "intend," or "project" or the negative of these words or other variations on these words or comparable terminology. To the extent that statements in this release are not strictly historical, including without limitation statements as to our ability to improve the outcomes of patients diagnosed with cancer, the potential clinical utility of our proprietary technology platform and the utility and commercial success of our EmpowerTC offering, such statements are forward-looking, and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The reader is cautioned not to put undue reliance on these forward-looking statements, as these statements are subject to numerous risk factors as set forth in our
References: |
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[1] |
Cancer Statistics Center." American Cancer Society, www.cancerstatisticscenter.org. Accessed 18 March 2019. |
[2] |
Corcoran, NM et al. Underestimation of Gleason score at prostate biopsy reflects sampling error in lower volume tumours. BJU Int. 2012 Mar;109(5):660-4. |
[3] |
Perlis, N et al. Limitations in Predicting Organ Confined Prostate Cancer in Patients with Gleason Pattern 4 on Biopsy: Implications for Active Surveillance. J Urol. 2017 Jan;197(1):75-83. |
[4] |
Harris WP, et al. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol 2009; 6: 76–85. |
Contact:
LHA Investor Relations
Jcain@lhai.com
310-691-7100
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