December 4, 2018 Michael W. Nall Chief Executive Officer and President Biocept, Inc. 5810 Nancy Ridge Drive San Diego, CA 92121 Re: Biocept, Inc. Registration Statement on Form S-1 Filed November 28, 2018 File No. 333-228566 Dear Mr. Nall: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Ruairi Regan at 202-551-3269 with any questions. Sincerely, Division of Corporation Finance Office of Beverages, Apparel and Mining cc: Charles J. Bair, Esq.