Biocept and UT Southwestern Medical Center Announce Clinical Study to Profile and Monitor Non-Small Cell Lung Cancer Patients with ALK Rearrangements
"Identifying ALK rearrangements in patients with lung cancer has become important as new targeted therapies are available to help manage disease in patients harboring this type of alteration," said
"Demonstrating the clinical utility of our Target Selector™ platform in studies conducted by top researchers like
About ALK Rearrangements in
The ALK gene encodes the anaplastic lymphoma kinase (ALK) protein, which belongs to a family of receptor tyrosine kinases involved in transmitting cell surface signals to the inside of the cell. In approximately 5% of non-small cell lung cancer patients, a portion of the ALK gene is abnormally rearranged when DNA is replicated during cell division. Fusion of ALK DNA sequences to another gene results in the disruption of normal ALK protein function, causing uncontrolled cell growth as is characteristic in cancer. Various ALK gene arrangements, or translocations, have been observed in NSCLC; the majority of variants involve gene fusions between the ALK and EML4 genes.
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outcomes of cancer patients, the success of the
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