Biocept to Present Data at RAS-Targeted Drug Development Summit Showing Ability of Its Switch-BlockerTM Technology to Detect Rare Cancer Mutations
Company’s ultra-sensitive and quantitative assays support efforts to develop targeted therapies for cancers driven by a variety of genetic mutations
The Summit brings together academic and biopharmaceutical leaders to share insights and data to advance the successful development of targeted monotherapies and combination strategies for RAS-driven cancers. RAS proteins are frequently mutated in cancers. In particular, KRAS mutations are present in approximately 25% of tumors, making them one of the most common gene mutations linked to cancer. They are drivers of some of the deadliest cancers, including lung, colorectal and pancreatic. As a result, there is significant interest among the biopharmaceutical and medical communities to develop and study new, highly targeted therapies to treat such cancers.
To support these efforts,
Biocept’s assays can be used to detect circulating tumor DNA (ctDNA) in tissue, blood and cerebrospinal fluid. For liquid biopsy applications, Switch-Blocker technology offers a 50- to 100-fold increase in mutant allele frequency of detection compared to conventional next-generation sequencing (NGS) and has been validated to 0.02% in blood. The technology offers similar analytical advantages in tissue, with the additional benefit of potentially reducing the Quantity Not Sufficient (QNS) rate because of the assay’s low sample input requirement compared to NGS-based assays.
“As this emerging area of therapeutic development rapidly grows, more companies are targeting rare and specific mutations with their drug candidates,” said
“Biopharmaceutical companies often require molecular assays that are customized to meet the specific needs of their trials,” said
The presentation, titled “The Ultra-Sensitive Detection of KRAS Mutations Using Switch-Blocker™ to Aid Therapeutic Decisions and Monitoring,” can be accessed here. To learn more about how Switch-Blockers in combination with Biocept’s array of liquid biopsy capabilities can help support both prognostic and predictive clinical trial enrichment, visit the virtual booth here.
Forward-Looking Statements Disclaimer
This release contains forward-looking statements that are based upon current expectations or beliefs, as well as a number of assumptions about future events. Although we believe that the expectations reflected in the forward-looking statements and the assumptions upon which they are based are reasonable, we can give no assurance that such expectations and assumptions will prove to have been correct. Forward-looking statements are generally identifiable by the use of words like “may,” "will," “could,” "designed," and "potential" or comparable terminology. To the extent that statements in this release are not strictly historical, including without limitation statements regarding the ability of Biocept’s patented Switch-Blocker technology to identify selected mutations down to a very small mutant frequency and the potential benefits thereof, Biocept’s ability to quickly and cost-effectively develop and build custom assays with high sensitivity and specificity, the potential of those assays to become companion diagnostics, the ability of CNSide cerebrospinal fluid assay to diagnose cancer that has metastasized to the central nervous system and the ability of Biocept’s molecular diagnostic assays to provide physicians with clinically actionable information to aid in the diagnosis, treatment and monitoring of patients with cancer, such statements are forward-looking, and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The reader is cautioned not to put undue reliance on these forward-looking statements, as these statements are subject to numerous risks and uncertainties, including the risk that supply disruptions may impact our ability to quickly and cost-effectively build custom assays, risks associated with the development and approval of a companion diagnostic test, and the risk that our products and services may not perform as expected. These and other risks are described in greater detail under the "Risk Factors" heading of our Quarterly Report on Form 10-Q for the quarter ended